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精子生成是一个复杂的细胞分化过程,其由精原干细胞经过一系列变化形成精子。在这个过程中细胞膜结构发生重构,细胞膜通透性和流动性发生阶段特异性改变,这其中离不开生殖细胞胞膜脂质的改变。脂质是生殖细胞胞膜的重要组成成分,它的含量和成分在精子生成过程中动态变化,若胞膜脂质代谢异常,可引起精子生成障碍,导致男性不育。生殖细胞胞膜脂质主要由胆固醇、磷脂和糖脂组成,它们分别在精子生成的不同阶段发挥细胞黏附、信号转导等作用,研究生殖细胞胞膜脂质对精子生成的影响有助于加深对精子生成机制的理解,为男性不育症的诊治开拓新的思路。
Spermatogenesis is a complex process of cell differentiation that produces sperm through a series of changes in spermatogonial stem cells. In this process, the remodeling of the cell membrane structure, cell membrane permeability and fluid phase-specific changes occur, which can not be separated from the germ cell membrane lipid changes. Lipid is an important component of the germ cell membrane, its content and composition in the dynamic process of sperm production, if the abnormal lipid metabolism of the cell membrane, can cause obstacles to sperm production, resulting in male infertility. Germ cell membrane lipid is mainly composed of cholesterol, phospholipids and glycolipids, which play a role in cell adhesion and signal transduction at different stages of spermatogenesis. Studying the influence of germ cell membrane lipid on spermatogenesis helps to deepen The understanding of the mechanism of sperm production, male infertility diagnosis and treatment to open up new ideas.