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目的 探索羟基喜树碱 (HCPT)联合化疗治疗晚期消化道肿瘤 ,特别是耐药肿瘤的可行性。方法 36例晚期消化道肿瘤采用HCPT +FD方案联合化疗 ,顺铂 6 0～ 80mg静滴d1、d8;羟基喜树碱 10mg静滴 (≥ 4h) ,d2～d6 ;5氟脲嘧啶 75 0mg静滴 (≥ 6h) ,d2～d6。第 4周重复 ,2周期后评价。结果 HCPT联合化疗总有效率 (CR +PR) 33.3% (12 / 36 ) ,对耐药肿瘤有效率达 2 5 % (6 / 2 4) ,毒副作用主要为消化道反应及骨髓抑制。结论 此方案对晚期消化道肿瘤有较好疗效 ,对耐药的晚期消化道肿瘤仍可获得较高的缓解率
Objective To explore the feasibility of HCPT combined with chemotherapy in the treatment of advanced gastrointestinal cancers, especially resistant tumors. Methods Thirty-six patients with advanced gastrointestinal cancer were treated with HCPT plus FD regimen combined with chemotherapy, cisplatin 60-80 mg intravenous drip d1, d8; hydroxycamptothecine 10 mg intravenous infusion (≥ 4 h), d2-d6; 5 fluorouracil 75 0 mg static Drops (≥ 6h), d2 ~ d6. Repeat week 4 and evaluate after 2 cycles. Results The total effective rate of HCPT combined with chemotherapy (CR +PR) was 33.3% (12 / 36), and the effective rate for resistant tumors was 25% (6 / 24). The toxic and side effects were mainly gastrointestinal reactions and bone marrow suppression. Conclusion This protocol has good curative effect for advanced gastrointestinal cancer, and still can obtain higher remission rate for resistant advanced gastrointestinal cancer.