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目的了解岳阳市淋病流行趋势,并追踪岳阳市淋病的传染源和优势菌株,为有效控制淋病提供科学依据。方法对全市2007-2010年疫情资料进行统计学分析,通过随机扩增多态性DNA技术(RAPD)对收集的83株淋球菌进行分子分型。结果 2007-2010年岳阳市共报告淋病492例,年平均发病率为2.44/10万,男性淋病发病率均高于女性。淋病病例主要集中在20~50岁的青壮年;职业构成以农民为主。83株淋球菌均产生了较多条带,经聚类分析,可分为8型,以A、B型为主;有3株淋球菌与其他菌株同源性低,各自单独组成RAPD型。结论岳阳市淋病的传染源主要有2个,同时,可能存在淋病的外源输入。应进一步加强对淋病的监测,并采取有针对性的措施,以有效控制淋病。
Objective To understand the epidemic trend of gonorrhea in Yueyang City and to track the source and dominant strains of gonorrhea in Yueyang City for the purpose of providing scientific evidence for effective control of gonorrhea. Methods The data of epidemic situation in the city from 2007 to 2010 were statistically analyzed, and the 83 strains of Neisseria gonorrhoeae collected were sequenced by random amplified polymorphic DNA (RAPD). Results A total of 492 cases of gonorrhea were reported in Yueyang from 2007 to 2010, with an average annual incidence of 2.44 per 100 000. The incidence of gonorrhea in males was higher than that of females. Gonorrhea cases are mainly concentrated in young adults aged 20 to 50; occupational composition to farmers. 83 strains of Neisseria gonorrhoeae produced more bands. According to the clustering analysis, they could be divided into 8 types, mainly A and B types. Three strains of Neisseria gonorrhoeae had low homology with other strains and formed RAPD type separately. Conclusion There are mainly two infectious sources of gonorrhea in Yueyang City. At the same time, there may be exogenous input of gonorrhea. Gonorrhea should be further strengthened monitoring, and take targeted measures to effectively control gonorrhea.