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The contact sensitivity evaluated by the car swelling test and the dynamic changes of epidermal Ia~+ dendritic cells (Ia~+ DECs) and Thy-1~+ dendritic cells (Thy-1~+ DECs) were studied in trinitrochlorobenzene (TNCB) sensitized different age group C3H/He mice after challenge. A significant increase of ear swelling was observed between 6 h and 10 days of both 8～10 week(wk)and 40～48 wk groups; the ear swelling indices of 8～10 wk group were significantly higher than those of 40～48 wk group from 18 h to 5 days; a significant decrcase of the densities of Ia~+DECs from 18 h to 48 h, followcd by a gradual increase reachinga significant increase of the densities of Ia~+DECs from 5 days to 21 days in both 8～10 wk and 40～48 wk groups, was observed; the densities of Thy-1~+ DECs significantly decreased from 18～48 h, followed by a gradual increase reaching a significant increase from 5 days to 21 days in both 8～10 wk and 40～48 wk groups.In the normal control groups,a significant decline of both Ia~+DECs and Thy-I~+DECs in the 40～48 wk group was observed. Results suggest that contact allergy may be diminished in aged mice. On the other hand, like Ia~+DECs, Thy-1~+DECs seem to be involved in the prosess of contact allergy.
The contact sensitivity evaluated by the car swelling test and the dynamic changes of epidermal Ia ~ + dendritic cells (Ia ~ + DECs) and Thy-1 ~ + dendritic cells (Thy-1 ~ + DECs) were studied in trinitrochlorobenzene (TNCB) sensitized A significant increase of ear swelling was observed between 6 h and 10 days of both 8 to 10 weeks (wk) and 40 to 48 wk groups; the ear swelling indices of 8 to 10 wk group were significantly higher than those of 40 ~ 48 wk from 18 h to 5 days; a significant decrcase of the densities of Ia ~ + DECs from 18 h to 48 h, followcd by a gradual increase reaching significant head of the densities of Ia ~ + DECs from 5 days to 21 days in both 8-10 wk and 40-48 wk groups, was observed; the densities of Thy-1 ~ + DECs significantly decreased from 18-48 h, followed by a gradual increase reaching a significant increase from 5 days to 21 days in both 8 to 10 weeks and 40 to 48 weeks groups.In the normal control groups, a significant decline of both Ia ~ + DECs and Thy-I ~ + DECs in the 40 ~ 48 wk group was observed. Results suggest that contact allergy may be diminished in aged mice. On the other hand, like Ia ~ + DECs, Thy-1 ~ + DECs seem to be involved in the prosess of contact allergy.