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目的介绍微透析技术在药物-蛋白结合研究中的应用。方法通过查阅近年来国内外相关文献,概述微透析技术的基本原理、特点、探针及影响探针相对回收率的主要因素,并重点介绍其在药物-蛋白结合研究中的应用。结果与结论与平衡透析法、超滤法相比,微透析技术是一项新兴的在体或离体取样技术,在药物-蛋白结合研究中具有显著的优越性和广阔的应用前景。
Objective To introduce the application of microdialysis in drug-protein binding research. Methods By reviewing the relevant literatures at home and abroad in recent years, the basic principles, characteristics, probes and the main factors influencing the relative recovery rates of microdialysis are summarized. The application of microdialysis in the study of drug - protein binding is also introduced. RESULTS AND CONCLUSION Microdialysis is a new in vitro or in vivo sampling technique compared with the equilibrium dialysis method and the ultrafiltration method. It has significant advantages and broad application prospects in drug-protein binding studies.