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目的探讨双侧原发性乳腺癌的临床诊断、治疗和预防。方法对68例经病理组织学证实的双侧原发性乳腺癌的临床特点、病理类型及治疗预后情况进行回顾性分析。结果 双侧原发性乳腺癌发病年龄呈年轻化趋势,绝经前妇女更易患双侧乳腺癌,主要预后因素与临床分期、最初的正确治疗和两侧乳腺癌的间距时间有关。2、5、10年生存率分别为82.4％(56,68)、48.3％(28,58)、22.2％(8/36)。结论45岁前未绝经女性乳腺癌术后随诊极为重要,早期诊断、积极治疗第二原发癌是提高生存率的关键。
Objective To investigate the clinical diagnosis, treatment and prevention of bilateral primary breast cancer. Methods The clinical features, pathological types and prognosis of 68 cases of bilateral primary breast cancer confirmed by histopathology were analyzed retrospectively. Results The incidence of bilateral primary breast cancer was younger, and premenopausal women were more likely to have bilateral breast cancer. The main prognostic factors were related to the clinical stage, the initial correct treatment and the interval time of breast cancer on both sides. The 2, 5, 10 year survival rates were 82.4% (56,68), 48.3% (28,58) and 22.2% (8/36), respectively. Conclusion The postoperative follow-up of women without premenopausal women before the age of 45 is extremely important. Early diagnosis and active treatment of the second primary cancer are the key to improve the survival rate.