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目的:探讨血清CG和ALT同步检测对肝病的诊断意义。方法:CG用RIA、ALT用全自动生化分析仪两次同步检测急肝162例,慢迁肝108例,慢活肝132例,肝硬化85例,肝癌55例及60例正常组。结果:急肝首检CG和ALT同步升高与正常组比较均具有极显著意义(P<0.001),在末次测定时ALT复常且CG也迅速转阴,两者比较无差异(P>0.05);慢活肝、肝硬化、肝癌则在后期ALT大多数回复正常时CG仍呈高水平,两者比较具有极显著性差异(P<0.001),肝癌组CG又显著高于急慢性非癌性肝病(P<0.001)。结论:血清CG和ALT同步检测更能全面反映肝病患者的肝脏整体病变,动态观察病情及区别良恶性肝病。
Objective: To investigate the diagnostic value of synchronous detection of serum CG and ALT in the diagnosis of liver disease. Methods: 162 cases of acute liver, 108 cases of slow-moving liver, 132 cases of slow-living liver, 85 cases of liver cirrhosis, 55 cases of liver cancer and 60 cases of normal group were detected simultaneously by RIA and ALT using two automatic biochemical analyzers. Results: The systolic elevation of CG and ALT in the first stage of acute liver injury was significantly higher than that in the normal group (P <0.001). ALT was normal and CG was rapidly negative in the last measurement, there was no difference between the two groups (P> 0.05 ). CG was still high in patients with chronic liver, liver cirrhosis and hepatocellular carcinoma after the majority of patients returned to normal at the later stage of ALT (P <0.001), CG of hepatocellular carcinoma was significantly higher than that of acute and chronic non-cancerous Sexual liver disease (P <0.001). Conclusion: Simultaneous detection of serum CG and ALT can fully reflect the overall liver disease in patients with liver disease, dynamic observation of the disease and the differentiation of benign and malignant liver disease.