报告１ 例原发性皮肤中心母细胞淋巴瘤。患者，男，９２ 岁。右小腿被蚊虫叮咬后出现肿块１年半， 增多、扩大、破溃伴左小腿肿块２ 个月。血常规、Ｘ 光胸片、腹部Ｂ 超、骨髓检查未见异常。病检示肿瘤细胞形态似中心母细胞， 免疫组化证实瘤细胞为Ｂ 细胞性。ＥＢＥＲ 原位杂交未检测到ＥＢ 病毒。患者未作放化疗，９ 个月后死亡。 One case of primary skin-centered mother cell lymphoma was reported. Patient, male, 92 years old. After the right calf was bitten by mosquitoes, a lump appeared for 1 year and a half. It increased, expanded, and ruptured with a left lower leg mass for 2 months. Blood tests, X-ray chest radiographs, abdominal ultrasonography, and bone marrow examinations were normal. The pathological examination showed that the tumor cells resemble the central mother cells. The immunohistochemistry confirmed that the tumor cells were B cells. EBER in situ hybridization did not detect EB virus. The patient did not undergo chemotherapy and died 9 months later.