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巯甲丙脯酸(Captopril,CTP)治疗充血性心力衰竭(CHF)已有十年的历史。然而用 CTP 治疗的心衰病人15%可产生首剂低血压,长期治疗时偶可出现肾功能损害,为了尽早发现和预防 CTP 的副作用,制定某些原则是必要的.一、治疗前准备①排除明显主动脉、二尖瓣或颈动脉狭窄.否则可引起脑或冠状动脉灌注减少的窃血综合征.②纠正低钠血症。血清钠<135mmol/L 的心衰病人,初始治疗时应慎重。③寻找低血容量的临床征象。低血容量的病人应用 CTP 常引起低血
Captopril (CTP) has been used for 10 years in the treatment of congestive heart failure (CHF). However, 15% of patients with heart failure treated with CTP can produce the first dose of hypotension, renal function can be even occasionally treated with long-term treatment, in order to detect and prevent side effects of CTP as soon as possible, to develop certain principles are necessary. Clear obvious aortic, mitral or carotid stenosis, otherwise can lead to brain or coronary perfusion reduced steal syndrome. ② correct hyponatremia. Serum sodium <135mmol / L of heart failure patients, the initial treatment should be careful. ③ looking for hypovolemic clinical signs. CTP is often caused by low blood volume in patients with low blood