Misonidazale和甲硝羟乙唑(灭滴灵)等硝基化合物是目前提高实体瘤中乏氧细胞辐射敏感较好的一类亲电子化合物,由于其对神经系统毒副作用较大,因而限制了该类药物的临床应用。为了提高其辐射增敏疗效而降低其神经毒性,我们合成了一种具有亲肿瘤和辐射增敏的新型的双功能化合物——甲硝羟乙唑衍生物(CM)。经元素分析、mp测定、TLC、纸电泳、紫外及红外光谱 The nitro compounds such as Misonidazale and metronidazole (mitomil) are currently a class of electrophilic compounds that improve the radiosensitivity of hypoxic cells in solid tumors. Because of their toxic side effects on the nervous system, they limit the The clinical application of drugs. In order to improve its radiosensitivity and reduce its neurotoxicity, we have synthesized a novel bifunctional compound with pro-tumor and radiation sensitization--metronidazole derivative (CM). Elemental analysis, mp determination, TLC, paper electrophoresis, UV and IR