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目的 探讨心肌缺血预适应 (IP)对急性心肌梗死 (AMI)临床及预后的近期影响。方法 根据心肌梗死前有无心肌缺血证据或 (和 )心绞痛病史将 198例患者分为A、B两组。对其临床资料进行回顾分析。结果 A组小面积心肌梗死发生率高于B组 ,而肌酸磷酸激酶 (CK)和同工酶 (CK MB)峰值、严重心脏并发症和梗死后心绞痛发生率、近期住院病死率均明显低于B组。结论 既往心绞痛促进冠状动脉侧支循环的建立 ,发病前心绞痛可能促进IP产生 ,二者协同对AMI后的心肌细胞起保护作用。
Objective To investigate the immediate effect of myocardial ischemic preconditioning (IP) on the clinical and prognosis of acute myocardial infarction (AMI). Methods According to the presence of evidence of myocardial ischemia before myocardial infarction or history of angina pectoris, 198 patients were divided into A and B groups. The clinical data of a retrospective analysis. Results The incidence of small-area myocardial infarction in group A was higher than that in group B, while the peak values of CK and CK MB, the incidence of serious cardiac complications and post-infarction angina and the recent in-hospital mortality were significantly lower In group B CONCLUSIONS: Previous angina pectoris promoted the establishment of coronary collateral circulation. Pre-onset angina pectoris may promote the production of IP. Synergistic angiogenesis may play a protective role in cardiomyocytes after AMI.