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目的 :探讨卵巢良恶性肿瘤中 CD4 4V6 与 PCNA的表达及其临床意义。方法 :应用免疫组化 SP法对 42例恶性卵巢肿瘤、 2 4例良性卵巢肿瘤和 10例正常卵巢组织中 CD4 4V6 与 PCNA的表达进行检测。结果 :CD4 4V6 与 PCNA的表达特点相似 ,两者在恶性卵巢肿瘤中的表达均高于在良性卵巢肿瘤及正常卵巢中的表达 ;在发生转移的恶性卵巢肿瘤中的表达均高于未发生转移的恶性卵巢肿瘤中的表达。结论 :CD4 4V6 与 PCNA在恶性卵巢肿瘤的发生、发展及浸润、转移中起重要作用 ,可以作为预测恶性卵巢肿瘤转移潜能的指标
Objective: To investigate the expression of CD4 4V6 and PCNA in benign and malignant ovarian tumors and its clinical significance. Methods: The expressions of CD4 4V6 and PCNA in 42 cases of malignant ovarian tumor, 24 cases of benign ovarian tumor and 10 cases of normal ovarian tissue were detected by immunohistochemical SP method. Results: The expressions of CD4 4V6 and PCNA were similar in both malignant ovarian tumors and normal ovarian tumors. The expression of CD4 4V6 and PCNA in malignant ovarian tumors was higher than that in non-ovarian tumors Of malignant ovarian tumors. Conclusion: CD4 4V6 and PCNA play an important role in the occurrence, development, infiltration and metastasis of malignant ovarian tumors and may be used as an index to predict the metastatic potential of malignant ovarian tumors