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糖尿病(Diabetes Mellitus,DM)血管并发症是糖尿病最常见的慢性并发症,直接关系到糖尿病患者的生活质量,也是糖尿病患者致死致残的主要原因。血管内皮功能损伤被认为是糖尿病血管并发症的始动因素和中心环节,近年来糖尿病性高脂血症与血管内皮损伤的关系成为医学界研究的一个热点。本文将从高糖、高脂、氧化应激、胰岛素抵抗和炎症反应等方面对糖尿病性高脂血症血管内皮损伤的机制做一简要综述。
Diabetes Mellitus (DM) Vascular complications are the most common chronic complications of diabetes. They are directly related to the quality of life of diabetic patients and are also the main cause of death and disability in diabetic patients. Vascular endothelial dysfunction is considered as the starting factor and central part of diabetic vascular complications. In recent years, the relationship between diabetic hyperlipidemia and vascular endothelial injury has become a hot research topic in medical field. This article will give a brief overview of the mechanism of vascular endothelial injury in diabetic hyperlipemia from the aspects of high glucose, high fat, oxidative stress, insulin resistance and inflammatory reaction.