目的研究乙型肝炎纤维组织增生的动态变化．方法对１８３８例肝活检样进行组化、免疫组化、电镜观察，并对其中１１０例２次以上随访的肝活检样本作了追踪研究．结果急性期网状、胶原纤维轻微增生，而慢性期则以胶原、弹力纤维（重型）占优势，特别在肝硬变期为显著（Ｐ＜００１），表明其呈梯度变化；在纤维组织动态变化中，血管增生及纤维化、ＦＮ，ＬＮ，ⅣＣｏ，αＳＭＡ表达也随之升降；随访研究表明，增生的纤维组织是可逆的，但降解吸收较缓慢．结论乙型肝炎肝纤维化是可逆的 Objective To study the dynamic changes of hepatitis B fibrosis. Methods 1838 liver biopsy samples were histopathologically, immunohistochemically and electron microscopically observed and 110 liver biopsy samples were followed up for more than two follow-up studies. Results Acute reticular and collagen fibers proliferated slightly, while collagen and elastic fibers (heavy type) were predominant in chronic phase, especially in cirrhosis (P <001), indicating a gradient change. Dynamic changes in tissue, vascular proliferation and fibrosis, FN, LN, Ⅳ  Co, α  SMA expression also will rise; follow-up studies have shown that the proliferation of fibrous tissue is reversible, but the degradation of absorption more slowly. Conclusion Hepatic fibrosis of hepatitis B is reversible