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近年来,微小RNA(microRNA、miRNA)对血管生理和病理性结构改变的研究越来越备受关注。其中,miR-221/222已被证实参与调节多个重要的血管生物学行为,如血管新生、内膜增生、伤口愈合及血管老化等[1]。血管重塑是血管新生和损伤修复,维持血管功能和结构完整,防止血栓形成的关键机制。然而,血管重塑在动脉粥样硬化血管中则是斑块增长的一种适应性反应。研究发现,血管重塑与miR-221/222的
In recent years, the research of micro-RNA (miRNA) on the changes of vascular physiology and pathological structure has drawn more and more attention. Among them, miR-221/222 has been shown to be involved in the regulation of several important vascular biological behaviors such as angiogenesis, neointimal hyperplasia, wound healing and vascular aging [1]. Vascular remodeling is a key mechanism for angiogenesis and injury repair, maintaining vascular function and structural integrity, and preventing thrombosis. However, vascular remodeling is an adaptive response to plaque growth in atherosclerotic vessels. The study found that vascular remodeling with miR-221/222