采用硅胶、RP-18、Sephadex LH-20等多种材料进行分离纯化,通过理化方法和波谱分析进行结构鉴定,从担子菌薄皮干酪菌(Tyromyces chioneus)发酵液的乙酸乙酯提取部位分离并鉴定了4个化合物,它们分别为:tyromol A(1)、tyromol B(2)、15-hydroxy-6α,12-epoxy-7β,10αH,11βH-spiroax-4-ene(3)和agripilol C(4)。其中化合物1和2为新的倍半萜,化合物3和4均为首次从该真菌中分离得到。 The materials were separated and purified by silica gel, RP-18, Sephadex LH-20 and other materials. The structures were identified by physico-chemical methods and spectral analysis. The structures were isolated and identified from the ethyl acetate extract of the basidiomycetes fermentation broth Four compounds were identified as tyromol A (1), tyromol B (2), 15-hydroxy-6α, 12-epoxy-7β, 10αH, 11βH-spiroax-4-ene and agripilol C ). Compounds 1 and 2 were new sesquiterpenoids. Compounds 3 and 4 were isolated from this fungus for the first time.