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Wnt蛋白及其受体、调节蛋白等一起组成了复杂的信号通路,它与胚胎正常发育、细胞的增殖与分化以及肿瘤形成密切相关。Wnt信号通路与肝细胞癌的关系,近年来受到广泛关注,得到了深入的研究。作者就W nt信号通路及其调节蛋白之间相互作用,Wnt信号通路与肝细胞癌发生发展、血管形成、侵袭和转移等方面的关系作一综述。
Wnt protein and its receptors, regulatory proteins together constitute a complex signal pathway, which is closely related to normal embryonic development, cell proliferation and differentiation and tumor formation. The relationship between Wnt signaling pathway and hepatocellular carcinoma has drawn extensive attention in recent years and has been deeply studied. The author reviews the relationship between Wnt signaling pathway and its regulatory proteins, Wnt signaling pathway and the development of hepatocellular carcinoma, angiogenesis, invasion and metastasis.