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幽门螺杆菌（Hp）感染是十二指肠球部溃疡（DU）的重要致病因素，与溃疡复发的关系尤为密切。根除Hp感染可显著降低DU的复发率。由胶体迹、甲硝华、四环素（或阿莫西林）组成的三联疗法是目前最有效的根除Hp感染疗法之一，但甲硝唑耐药菌株影响及副作用较多的缺点，临床应用受
Helicobacter pylori (Hp) infection is an important risk factor for duodenal ulcer (DU), and the relationship between ulcer recurrence is particularly close. Eradication of Hp infection can significantly reduce the recurrence rate of DU. The triple therapy with colloidal trace, metronidazole and tetracycline (or amoxicillin) is one of the most effective treatments for eradicating Hp infection at present, but the metronidazole-resistant strains have the disadvantage of more side effects and clinical application