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应用放射免疫分析，初步观察了特非那丁引起的豚鼠血浆环磷酸腺苷（ｃＡＭＰ）相对浓度变化。结果表明，特非那丁组显著高于空白对照组，可间接反映细胞内及肺组织ｃＡＭＰ含量的变化，并提示特非那丁这一作用也可对胞膜表面β２肾上腺素受体（β２ＡＲ）产生影响，引起β２ＡＲ的异种向下调节。
Radioimmunoassay was used to observe the relative concentration of cAMP in guinea pigs induced by terfenadine. The results showed that the terfenadine group was significantly higher than the blank control group, which indirectly reflects the intracellular and lung cAMP content changes, suggesting that the role of terfenadine can also membrane surface β2 adrenergic receptor (β2AR ), Causing a down-regulation of the xenogeneic β2AR.