细胞骨架是细胞内机械力传递链的一个组分，肌球蛋白作为细胞骨架的主要组成蛋白，对细胞受到外界力作用时产生的效应具有一定的调控作用，当细胞内的肌球蛋白的表达、结构以及活性发生改变时，细胞的力学效能也会发生相应的改变，从而影响细胞的功能以及组织结构的改变。肌球蛋白轻链的磷酸化、重链各亚型间的转化以及Rho GTP酶信号通路在对细胞生物力学效应的调控中起着一定的作用。“,”Cytoskeleton is a component of mechanical force transmission chain .As the main protein in forming cytoskeleton in cells, myosin plays a role in regulating the effect produced by cells when they are forced by the external force.When the expression, structure and activity of myosin changes, mechanical effi-ciency of cells will have a corresponding change, thus affecting the cell function and organizational structure. Phosphorylated myosin light chain, transformation of subtypes in myosin heavy chain , and Rho GTPases sig-naling pathway play an important role in the regulation of cellular biological effects .In this article, we try to express the advanced research in myosin′s impact on cell biomechanics effect.In addition, we also discuss the generation mechanism of such effects.