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目的:观察归知糖疽颗粒对I型糖尿病大鼠周围神经和血管病变的影响。方法:采用链脲佐菌素糖尿病大鼠模型,试验分对照组、模型组、归知糖疽颗粒组(0.81,1.62,3.24 g·kg-1)、阳性对照药组,灌胃给药12周,以坐骨神经传导速度、摆尾温度阈值、血糖、体重、病理形态学为观察指标。结果:归知糖疽颗粒能延迟神经传导速度减慢,降低摆尾温度阈值,调节血糖及改善大鼠体重;病理学证实,可减少神经纤维断裂及轴索萎缩,减轻毛细血管内皮细胞肿胀,抑制炎细胞浸润。结论:归知糖疽颗粒对糖尿病大鼠周围神经及末梢血管损伤具有保护作用,以3.24 g·kg-1剂量组作用更为显著。
Objective: To observe the effect of Guixi Gouji granules on peripheral nerve and vascular lesions in type 1 diabetic rats. Methods: The model of streptozotocin-induced diabetic rats was divided into control group, model group, Guixi and Yinlu Granule group (0.81,1.62,3.24 g · kg-1), positive control group, intragastric administration of 12 Weeks, sciatic nerve conduction velocity, tail temperature threshold, blood glucose, body weight, pathological morphology as the observation. Results: Guiqi syrup can delay nerve conduction slowdown, reduce the tail temperature threshold, regulate blood glucose and improve body weight; pathology confirmed that can reduce nerve fiber rupture and axonal atrophy, reduce capillary endothelial cell swelling, Inhibit inflammatory cell infiltration. CONCLUSION: Guixi and Jiujian Granules have a protective effect on peripheral nerve and peripheral vascular injury in diabetic rats, and the effect is more significant at the dose of 3.24 g · kg-1.