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目的:探讨雷公藤多苷联合泼尼松治疗成人紫癜性肾炎的临床效果与安全性,为临床治疗成人紫癜性肾炎提供参考依据。方法:选取成人紫癜性肾炎患者120例,随机分为对照组和观察组各60例。对照组患者采用泼尼松进行治疗,观察组患者采用雷公藤多苷联合泼尼松进行治疗,比较两组患者的治疗效果。结果:经过治疗,观察组患者治疗总有效率为96.7%,明显高于对照组的83.3%,差异具有统计学意义(P<0.05);观察组患者复发率明显低于对照组,差异具有统计学意义(P<0.05);两组患者不良反应发生情况比较无统计学差异(P>0.05)。结论:雷公藤多苷联合泼尼松针治疗成人紫癜性肾炎患者临床效果确切,是一种安全、有效的治疗方法,值得临床推广应用。
Objective: To investigate the clinical effect and safety of tripterygium glycosides combined with prednisone in the treatment of adult purpura nephritis, and to provide a reference for the clinical treatment of adult purpura nephritis. Methods: 120 adult patients with purpura nephritis were randomly divided into control group and observation group, 60 cases each. Patients in the control group were treated with prednisone. Patients in the observation group were treated with tripterygium glycosides plus prednisone, and the treatment effect was compared between the two groups. Results: After treatment, the total effective rate of observation group was 96.7%, which was significantly higher than that of control group (83.3%), the difference was statistically significant (P <0.05); the recurrence rate of observation group was significantly lower than that of control group (P <0.05). There was no significant difference in adverse reactions between the two groups (P> 0.05). Conclusion: The clinical effect of tripterygium glycosides combined with prednisone needle in the treatment of adult purpura nephritis is a safe and effective treatment and is worthy of clinical application.