肼苯哒嗪用于控制高血压,经表明它的血管减压活性与血浆水平有密切关系。因此重要的是搞清楚口服后什么因素影响肼苯哒嗪的血浆浓度。一项报告指出,食物增加人体内肼苯哒嗪浓度。不过采用的分析方法尚有问题,故有人将食物对肼苯哒嗪生物利用度的影响重新进行了检验。研究对象为六名患原发性高血压的病人,其中四人是慢乙酰化者,二人是快乙酰化者。每人分别 Hydralazine is used to control high blood pressure, and it has been shown that its vasodepressor activity is closely related to plasma levels. It is therefore important to find out what factors affect the plasma concentration of hydralazine after oral administration. One report noted that food increases the hydralazine concentration in the human body. However, the analytical methods used still have problems, so some people have re-tested the impact of food on the bioavailability of hydralazine. The study population was six patients with essential hypertension, four of whom were slow acetylators and two were fast acetylators. Each person separately