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目的 :探讨原发性高血压 (EH)患者肾小球滤过率减退的相关因素。方法 :95例EH患者均进行放射性核素肾动态显像 ,根据肾小球滤过率 (GFR)有无减退分成两组 ,并进行年龄、病程、血脂、尿素氮 (BUN)、血肌酐 (Cr)、血尿酸 (UA)、纤维蛋白原 (Fib)、尿微量白蛋白 (MAU)、尿α1 微球蛋白 (α1 MG)、最大收缩压 (SBP max)、最大舒张压 (DBPmax)及肾有效血浆流量 (ERPF)的组间比较 ,同时进行多元回归统计分析。结果 :EH患者GFR下降组在年龄、病程、血Cr、肾有效血浆流量、尿α1 MG、SBPmax、DBPmax方面与GFR正常组比较差异均有显著性意义 (P <0 .0 1) ,总胆固醇、三酰甘油两组间未见明显差异 (P >0 .0 5 )。多元回归分析显示 :GFR水平与ERPF水平呈正相关 ,与舒张压呈负相关 (P <0 .0 1)。结论 :EH患者GFR减退是多种因素作用的结果
Objective: To investigate the related factors of glomerular filtration rate (GFR) decline in patients with essential hypertension (EH). Methods: Ninety-five patients with EH underwent dynamic imaging of radionuclide, and divided into two groups according to the presence or absence of glomerular filtration rate (GFR). The age, course of disease, serum lipids, blood urea nitrogen (BUN), serum creatinine Cr, UA, Fib, MAU, α1 MG, SBP max, DBP max, and renal Effective plasma flow (ERPF) comparison between groups, while multiple regression statistical analysis. Results: The GFR in EH patients were significantly different from those in normal GFR group (P <0.01) in terms of age, course of disease, blood Cr, renal effective plasma flow, urinary α1 MG, SBPmax and DBPmax , No significant difference between the two groups of triglyceride (P> 0.05). Multiple regression analysis showed that GFR level was positively correlated with ERPF level and negatively correlated with diastolic pressure (P <0.01). Conclusions: The decline of GFR in EH patients is the result of many factors