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sesamodil(SD-3211)的化学名为(+)-3,4-二氢-2-[5-甲氧基-2-[3-[N-甲基-N-[2-[(3,4-亚甲二氧基)苯氧基]乙基]胺]丙氧基]苯基]-4-甲基-3-氧-2H-1,4-苯并硫嗪富马酸盐,是一种新型钙拮抗剂。由于组织选择性不同,钙拮抗剂按其药理可分为选择性作用于血管,如硝苯啶及尼卡地平,或心脏,如维拉帕米及地尔硫(艹卓)两类。作者在离体平滑肌和心肌上将SD-3211对组织的选择性与这两类钙拮抗剂进行了比较。分别测定了SD-3211对血管以及对心房
The chemical name of sesamodil (SD-3211) is (+) - 3,4- dihydro-2- [5-methoxy-2- [3- [N- Methylenedioxy) phenoxy] ethyl] amine] propoxy] phenyl] -4-methyl-3-oxo-2H-1,4-benzothiazine fumarate is A new type of calcium antagonist. Due to the different tissue selectivity, calcium antagonists can be divided into two classes according to their pharmacological effects, such as nifedipine and nicardipine, or the heart, such as verapamil and diltiazem. The authors compared the tissue selectivity of SD-3211 to both types of calcium antagonists in isolated smooth muscle and myocardium. SD-3211 was measured on the blood vessels and on the atria, respectively