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4 1BB/ 4 1BBL是一组重要的共刺激分子 ,起初对于 4 1BB/ 4 1BBL研究主要集中于 4 1BB作为T细胞表面分子的共刺激作用。最近的证据显示 ,4 1BBL不只表现一个共刺激分子配基的作用 ,在本综述中 ,我们讨论了 4 1BBL作为共刺激分子配基的作用 :如对CD8+ T细胞的优先增殖和刺激作用 ,并进一步地讨论了 4 - 1BB/ 4 1BBL所介导的双信号传导机制 ,在肿瘤细胞表面表达 4 - 1BBL所引发的免疫机制做一回顾 ,探讨其用于肿瘤免疫治疗的价值。
4 1BB / 4 1BBL is a group of important costimulatory molecules. Initially, 4 1BB / 4 1BBL studies focused on 4 1BB as a co-stimulatory effect on T cell surface molecules. Recent evidence indicates that 4 1BBL does not function only as a co-stimulatory molecule, and in this review we discuss the role of 4 1BBL as a costimulatory molecule: preferential proliferation and stimulation of CD8 + T cells and Furthermore, the mechanism of the dual signal transduction mediated by 4 - 1BB / 4 1BBL was discussed. The immune mechanism induced by the 4 - 1BBL expression on the surface of tumor cells was reviewed, and its value in tumor immunotherapy was discussed.