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目的探讨乙型肝炎疫苗接种无免疫应答儿童复种不同剂量乙肝疫苗的免疫效果,为乙型肝炎免疫预防工作提供依据。方法严格筛选无应答儿童46名,随机分为两组,每组23人。两组用不同剂量(每剂分别为20ug,5ug)乙肝疫苗,按0、1、6免疫程序进行肌肉接种。完成7个月随访观察。结果无应答儿童复种20ug组21人产生抗体应答;复种5ug组16人产生抗体应答。无应答儿童复种20ug组抗-HBs阳性率和抗体阳性水平(GMT)均明显高于复种5ug组(P<0.01)。结论无应答儿童复种能起到改善免疫应答。大剂量(20ug)接种好于小剂量(5ug)接种。
Objective To investigate the immune effect of hepatitis B vaccine in different doses of hepatitis B vaccine without immunization in hepatitis B patients and provide basis for hepatitis B immunization prevention. Methods Strict screening of 46 children without response, were randomly divided into two groups of 23 people. Two groups with different doses (each dose were 20ug, 5ug) hepatitis B vaccine, according to 0,1,6 immunization program for muscle inoculation. Complete 7 months follow-up observation. Results There were 21 antibody responses in 20 μg of non-responders and 10 in 5 μg of antibodies. The anti-HBs positive rate and antibody positive level (GMT) in the non-responders 20μg group were significantly higher than that of the 5μg group (P <0.01). Conclusion Replenishment of non-responders can improve the immune response. High dose (20ug) vaccination is better than low dose (5ug) vaccination.