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【目的】观察精制蟒蛇油对D-半乳糖所致衰老小鼠皮肤组织的延缓衰老作用。【方法】选用昆明种小鼠,随机分为蟒蛇油高、中、低剂量组(中药高、中、低剂量组,剂量分别为10、5、2.5 mL/kg),维生素E组(剂量为50 mg/只),模型组和正常对照组;除正常对照组外,其他组均采用颈背部皮下注射D-半乳糖(剂量为1 g/kg)法复制亚急性衰老模型,同时各组皮肤涂布给药,连续42 d。取各组小鼠背部皮肤检测含水量、超氧化物歧化酶(SOD)活力和丙二醛(MDA)含量,并进行组织病理学检查。【结果】模型组皮肤含水量及SOD活力降低,MDA含量升高,与正常对照组比较差异具有显著性意义(均P<0.01);中药高、中、低剂量组及维生素E组均可升高皮肤含水量和SOD活力,降低MDA含量,与模型组比较差异有显著性意义(P<0.01),并可改善皮肤组织的病理形态变化。【结论】精制蟒蛇油具有一定延缓皮肤衰老的作用,其机制与其能增加皮肤含水量和SOD活力,降低MDA含量有关。
【Objective】 To observe the anti-aging effects of refined python oil on the skin of aging mice induced by D-galactose. 【Method】 Kunming mice were randomly divided into python oil high, medium and low dose groups (high, medium and low dose groups, the dose was 10,5,2.5 mL / kg), vitamin E group (dose was 50 mg / only), the model group and the normal control group; except for the normal control group, all the other groups were subcutaneously injected with D-galactose (1 g / kg) Coating administration, continuous 42 d. The skin of the mice in each group was tested for the water content, the activity of superoxide dismutase (SOD) and the content of malondialdehyde (MDA) in the skin of the mice in each group, and histopathological examination was performed. 【Results】 The results showed that the skin water content, SOD activity and MDA content in the model group were significantly lower than those in the normal control group (all P <0.01). The levels of high, middle and low dose of Chinese herbal medicine and vitamin E group increased High skin moisture content and SOD activity, reduced MDA content, compared with the model group, the difference was significant (P <0.01), and can improve the pathological changes of the skin tissue. 【Conclusion】 Refined python oil has a certain effect of delaying skin aging, and its mechanism is related to its ability to increase skin moisture content and SOD vitality and decrease MDA content.