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Poly(α-hydroxy octanoic acid) was first used as an additive for the preparation of electrospun ultra-fine fibers of poly(ethylene glycol)-b-poly(L-lactide)(PEG-PLLA).Ibuprofen was loaded in the electrospun ultra-fine fibers.The results from environmental scanning electron microscopy(ESEM),wide angle X-ray diffraction(WAXD) and differential scanning calorimetry(DSC) demonstrated that ibuprofen could be perfectly entrapped in the fibers electrospun from PEG-PLLA usingα-hydroxy octanoic acid or PEG-b-poly(α-hydroxy octanoic acid)(PEG-PHOA) as additives.Compared with electrospun PEG-PLLA fibers which entrapped 20 wt%ibuprofen,the PEG-PLLA electrospun fibers containing PEG-PHOA exhibited integral and robust after 1 week incubated in 37℃,pH 7.4 phosphate buffer solution with 10μg/mL proteinase K.Compared with electrospun fibers without PEG-PHOA,the concentration of proteinase K in release media had less effect on the release rate of ibuprofen.An unique release profile was found from PEG-PLLA fiber after the incorporation of PEG-PHOA. Enzyme degradation experiments demonstrated that PEG-PHOA but notα-hydroxy octanoic acid monomer was the crucial factor for integrity maintenance of the electrospun fibers,which may be due to the enzyme degradation tolerance property of the PEG-PHOA polymer additive.
Poly (α-hydroxy octanoic acid) was first used as an additive for the preparation of electrospun ultra-fine fibers of poly (ethylene glycol) -b-poly (L-lactide) ultra-fine fibers. The results from environmental scanning electron microscopy (ESEM), wide angle X-ray diffraction (WAXD) and differential scanning calorimetry (DSC) demonstrated that ibuprofen could be perfectly entrapped in the fibers electrospun from PEG-PLLA using α- (PEG-PHOA) as additive. Compared with electrospun PEG-PLLA fibers which entrapped 20 wt% ibuprofen, the PEG-PLLA electrospun fibers containing PEG-PHOA exhibited integral and robust after 1 week of incubation at 37 ° C, pH 7.4 phosphate buffer solution with 10 μg / mL proteinase K.Compared with electrospun fibers without PEG-PHOA, the concentration of proteinase K in release media had less effect on the release rate of ibuprofen. An unique release profile was found from PE G-PLLA fiber after the incorporation of PEG-PHOA. Enzyme degradation experiments demonstrated that PEG-PHOA but not alpha-hydroxy octanoic acid monomer was the crucial factor for integrity maintenance of the electrospun fibers, which may be due to the enzyme degradation tolerance of the PEG-PHOA polymer additive.