一、实验动物和实验方法简述做肺肿瘤诱发实验时,要根据研究的目的和各种实验方法选择动物,一般多用大鼠和地鼠,其次用小鼠。诱发实验性肺癌时,其结果常受动物和致癌物的选择以及投与方法等因素的影响。在吸入法致癌方面,见有大鼠吸入三甲基胆蒽(MCA)诱发了肺腺瘤,小鼠长期吸入P-苯醌出现腺瘤样增生和癌变的报告。Hammond等成功地给狗自然吸入香烟烟雾诱发了肺 First, experimental animals and experimental methods briefly described Do lung tumor evoked experiments, according to the purpose of the study and a variety of experimental methods to select the animals, the general use of rats and hamsters, followed by mice. When experimental lung cancer is induced, the results are often influenced by factors such as the choice of animal and carcinogen and the method of administration. In the case of inhalation carcinogenesis, there were reports of inhalation of trimethylcholestane (MCA) in rats that induced lung adenomas and reports of adenomatous hyperplasia and carcinogenesis in mice with long-term inhalation of P-benzoquinone. Hammond and others successfully inhaled cigarette smoke into the lungs