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Ｋａｐｐａ－硒化卡拉胶给大鼠ｉｇ５．１５．４５ｍｇ·ｋｇ－１．ｇｄ．共１４次．在１５．４５ｍｇ·ｋｇ－１剂量组能显著提高注射阿霉素（ｉＰ３ｍｇ·ｋｇ－１，隔日１次．共４次）之大鼠全血谷胱甘肽过氧化物酶活性（Ｐ＜０．０５）．在３个剂量组不同程度改善心电图变化。对阿霉素引起的白细胞、血小板的减少也有抑制（Ｐ＜０．０５或Ｐ＜０．０１）．大剂量卡拉胶组．还可改善阿霉素所致心脏与肝脏的形态改变。Ｐ＜０．０１表３各组大鼠血小板计数值（×１０９·Ｌ－１，）各组均与阿霉素组比较．＊Ｐ＜０．０５，Ｐ＜０．０１＊Ｐ＜０．００１２．２，４对心及肝脏病理切片形态观察给药结束后第５周处死动物，取心、肝脏以３．３×１０３μｍｏｌ·Ｌ－１福尔马林固定，石蜡切片（５μｍ厚），ＨＥ染色，光镜检查。结果表明，阿霉素对心脏有明显的毒性作用，表现为心肌明显的空泡变，灶性肌溶解，而加亚硒酸钠和Ｋａｐｐａ－硒化卡拉胶，其变性程度及范围有改善，表现为肌细胞空泡变性及肌溶解的数量有较明显的减少。阿霉素对肝脏的毒性作用，表现为肝细胞明显的空泡变性及少量的点状坏死，如用硒化卡拉胶或亚硒酸钠肝细胞变性范围程度有不同改善，表现为空泡变性范围缩小，点状坏死减少，尤?
Kappa-selenated carrageenan gave rat ig 5. 15.45 mg · kg -1. gd. A total of 14 times. In 15.45mg · kg-1 dose group, the glutathione peroxidase activity in whole blood of rats injected with doxorubicin (iP3mg · kg-1, once every other day for 4 times) .05). The three dose groups improved ECG changes to varying degrees. Doxorubicin-induced leukocyte, platelet reduction was also inhibited (P <0.05 or P <0.01). High-dose carrageenan group. Can also improve doxorubicin-induced heart and liver morphological changes. P <0.01 Table 3 platelet count in each group (× 109 · L-1,) Each group compared with doxorubicin group. * P <0.05, P <0.01 * P <0.0012.2,4 Observations on the shape of heart and liver pathological sections After the end of the administration, the animals were sacrificed at the fifth week, and the heart and liver were infused with 3.3 × 103 μmol L-1 formalin fixed, paraffin sections (5 μm thick), HE staining, light microscopy. The results showed that doxorubicin has a significant toxic effect on the heart, manifested as myocardial vacuolar changes, focal muscle solubilization, and add sodium selenite and Kappa-selenated carrageenan, the extent and extent of degeneration has improved, The performance of myocytes vacuolar degeneration and the number of muscle lysis significantly reduced. Adriamycin on the liver toxicity, manifested as obvious vacuolar degeneration of hepatocytes and a small amount of punctate necrosis, such as the use of selenized carrageenan or sodium selenite hepatic degeneration range of varying degrees of improvement showed vacuolar degeneration Narrow range, reduced punctate necrosis, especially?