目的 :应用小儿危重病例评分法和多系统器官衰竭诊断标准评估急性中毒患儿病情严重程度和预后。方法 :对1 997年 1月至 2 0 0 2年 1 2月收治的 96例急性中毒患儿 ,在住院期间进行 3次评分 ,按评分值分为 3组 :非危重病组 (～ 1 0 0 ) ,危重组 (～ 80 )、极危重组 (～ 70 )。结果 :首次评分显示 3组患儿死亡率随分值降低而逐渐增高即非危重组为 0 ,危重组1 2 .82 % ,极危险重组为 31 .5 8% ,三组比较差异有显著性 (P<0 .0 1 ) ,第 2、3次评分结果与首次相似 ,评分越低死亡率越高。 3组患儿 MSOF发生率随分值降低而升高 ,依次为 2 .6 3%、33.33%、78.95 % ,差异有显著性 (P<0 .0 1 )。结论 :小儿危重病例评分法和多系统器官功能衰竭诊断标准可较准确判断急性中毒患儿的病情和预后 ,评分值越低 ,MSOF发生率越高 ,死亡率越高 OBJECTIVE: To evaluate the severity and prognosis of children with acute poisoning by applying the pediatric critical illness score and multi-system organ failure diagnostic criteria. Methods: Ninety-six children with acute poisoning admitted from January 1997 to February 2002 were enrolled and scored three times during the hospital stay. The patients were divided into three groups according to the scores: non-critically ill patients (~ 10 0), critically ill (~ 80), critically endangered (~ 70). Results: The first score showed that the mortality rate of three groups of children was gradually increased with the decrease of score, which was 0 in non-critically ill group, 12.82% in critically ill group and 31.58% in extremely dangerous group, with significant difference among the three groups P <0. 01), the second and third scoring results similar to the first, the lower the score the higher the mortality rate. The incidence of MSOF in 3 groups of children increased with the decrease of scores, which were 2.63%, 33.33% and 78.95% respectively, the difference was significant (P <0.01). Conclusion: The score of pediatric critical illness and multi-system organ failure diagnostic criteria can be more accurate diagnosis of acute poisoning in children with the disease and prognosis, the lower the score, the higher the incidence of MSOF, the higher the mortality rate