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目的 :探讨醛氢叶酸 (CF)联合氟尿嘧啶 ( 5 -FU )和顺铂 (PDD)区域化疗配合放疗治疗中、晚期和复发癌症提临床疗效。方法 :对 3 0例失去手术而行放、化疗的中、晚期和复发癌症患者随机分为A、B两组 ,A组为单用FD方案区域化疗后再行放疗 ,B组为CF联合DF方案区域化疗后再行放疗。结果 :放疗结束后A、B两组症状均有不同程度缓解 ,症状缓解率均达 10 0 % ,但缓解的程度A组低于B组 ,A、B两组近期疗效分别为 80 %、93 3 % ,但B组的毒性反应明显高于A组。结论 :在DF方案区域化疗中 ,联合CF化疗配合放疗治疗中、晚期和复发癌症可有效地控制局部肿瘤 ,提高近期疗效 ;但也增加消化道粘膜的毒性反应 ,在临床治疗中值得引起注意。
Objective: To investigate the clinical efficacy of combination chemotherapy with radiofrequency folate (CF) and fluorouracil (5 -FU) and cisplatin (PDD) in the treatment of moderate, advanced and recurrent cancer. Methods: Thirty (30) patients with moderate, advanced and recurrent cancers who had missed surgery were randomly divided into A and B groups. Group A received radiotherapy only after regional chemotherapy with FD regimen, and group B received CF combined with DF Regional chemotherapy after radiotherapy. Results: After the end of radiotherapy, the symptoms of both A and B groups were relieved to some extent, and the rate of remission was up to 100%. However, the degree of remission was lower in group A than in group B, and the short-term effects in group A and B were 80% and 93%, respectively 3%, but the toxicity of group B was significantly higher than that of group A. CONCLUSION: Combination of chemotherapy with radiotherapy and chemotherapy combined with radiotherapy in the treatment of middle and advanced stage and recurrent cancer in DF regimen can effectively control local tumors and improve short-term efficacy. However, they also increase the toxicity of gastrointestinal mucosa and deserve attention in clinical treatment.