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目的:探讨不同部位急性脑梗死患者血浆肌钙蛋白I(cTnI)、肌酸激酶同工酶(CK-MB)的变化及临床意义。方法:检测342例急性脑梗死患者及300例对照组的cTnI及CK-MB,分析比较不同部位脑梗死患者的血浆cTnI及CK-MB的变化,并随访6个月的死亡情况。结果:急性脑梗死患者中出现cTnI、CK-MB增高的比例明显增加(P<0.001、P<0.01)。cTnI、CK-MB升高主要见于岛叶梗死患者,右侧岛叶脑梗死cTnI升高发生率高于左侧,双侧岛叶梗死CK-MB升高发生率无明显差异;cTnI、CK-MB升高者病死率明显升高,预后差。结论:急性脑梗死早期异常与梗死部位、病情严重程度及预后有关,而岛叶梗死患者的cTnI及CK-MB异常发生率高、病情重及预后差。
Objective: To investigate the changes and clinical significance of plasma cTnI and CK-MB in patients with acute cerebral infarction. Methods: The cTnI and CK-MB in 342 patients with acute cerebral infarction and 300 controls were measured. The changes of plasma cTnI and CK-MB in patients with cerebral infarction at different sites were analyzed and compared. The deaths were followed up for 6 months. Results: The percentage of cTnI and CK-MB increased significantly in patients with acute cerebral infarction (P <0.001, P <0.01). cTnI and CK-MB were mainly found in patients with insular island infarction. The incidence of elevated cTnI in the right islees was higher than that in the left ones and there was no significant difference in the incidence of CK-MB in the bilateral islets. The cTnI, CK- MB elevated mortality was significantly higher, the prognosis is poor. Conclusion: The early stage of acute cerebral infarction is related to the infarction location, severity of disease and prognosis. However, the incidence of cTnI and CK-MB abnormalities in patients with islet infarction is high, and the severity and prognosis are poor.