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报告了用气相色谱法测定血浆支链酮酸(Branched-ChainKetoAcids;BCKA’s)浓度,以及静脉输注高浓度L-缬氨酸(L-valine,val)治疗半乳糖胺引起兔肝昏迷(HepaticComa; HC)的结果。HC兔血浆BCKA’S明显低于正常组水平,相对应的支链氨基酸(Branched-Ghain Amino acids;BCAA’S)及其它氨基酸多数增高,芳香族氨基酸(AromaticAminoAcids;AAA'S)大幅度升高,用5%val静脉输注48h,血浆BCKA’S提高约3倍,BCAA’S改变不大,AAA’S下降37%;血浆BCKA’S/BCAA’S、BCAA’S/AAA’S比值也明显增高。提示,高浓度val能纠正HC血浆BCKA’S及主要氨基酸紊乱。
Reported the determination of plasma concentrations of Branched-Chain Keto Acids (BCKA’s) by gas chromatography and the treatment of galactosamine-induced hepatic hepatic coma by high-dose intravenous infusion of L-valine (val) HepaticComa; HC) results. The BCKA’s in plasma of HC rabbits were significantly lower than that of the normal group, the majority of branched-chain amino acids (BCAA’s) and other amino acids were increased, and the Aromatic Amino Acids (AAA’s) were greatly increased , With 5% val intravenous infusion 48h, plasma BCKA’s increased about 3 times, BCAA’S little changed, AAA’S decreased 37%; plasma BCKA’S / BCAA’S, BCAA’S / AAA’S ratio Also significantly higher. Tip, high concentrations of val can correct HC plasma BCKA’S and major amino acid disorders.