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目的：通过两组病例对照研究，以证实微波组织凝固治疗是否可作为治疗舌鳞癌原发灶的一种治疗方法，非比较其与传统手术方法的优缺点。方法：80例舌鳞状细胞癌患者，依临床分期、性别、年龄相应随机分组。实验组病例原发灶进行微波组织凝固治疗，颈部行颈淋巴结清扫术，同时行颈外动脉或舌动脉结扎术。对照组病例Ⅰ、Ⅱ期患者采用颈淋巴结清扫术加半舌切除术，Ⅲ、Ⅳ期患者采用舌癌联合根治术。结果：通过比较治疗后2年的原发灶复发、颈淋巴结转移、远处转移情况及2年生存率，两组无显著性差异（P=0．675，0．747，1．0和0．713）。比较口腔功能及外形的满意程度，实验组优于对照组（P=0．00125，P＜0．0001）。术后创面出血及呼吸困难是微波组织凝固治疗舌鳞癌主要并发症。结论：在行综合治疗同时微波组织凝固治疗的近期疗效与传统方法相同，具有保全口腔功能和外形的优点，它可以作为治疗舌鳞癌原发病灶的手段之一。
Objective: To compare the two groups of case-control studies to confirm whether microwave tissue coagulation therapy can be used as a treatment of tongue squamous cell carcinoma primary treatment, not to compare with the advantages and disadvantages of traditional surgical methods. Methods: Eighty tongue squamous cell carcinoma patients were randomly divided into groups according to clinical staging, gender and age. Experimental group of patients with primary tumor microwave coagulation therapy, neck dissection of cervical lymph nodes, while the external carotid artery or tongue artery ligation. Patients in control group Ⅰ and Ⅱ were treated with cervical lymph node dissection and half tongue resection. Patients in stage Ⅲ and Ⅳ were treated with tongue cancer combined with radical mastectomy. Results: There was no significant difference between the two groups (P = 0.675, 0.747, 1.0 and 0) by comparing the recurrence of primary tumor, cervical lymph node metastasis, distant metastasis and 2-year survival rate .713). Compared with the oral function and appearance satisfaction, the experimental group was better than the control group (P = 0.00125, P <0.0001). Postoperative wound bleeding and dyspareunia are the main complications of microwave coagulation in the treatment of tongue squamous cell carcinoma. Conclusion: The curative effect of traditional microwave coagulation therapy is the same as that of the traditional method. It has the advantages of preservation of oral function and appearance, and it can be used as one of the means to treat primary lesions of tongue squamous cell carcinoma.