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目的观察高压氧联合药物三联法治疗急性缺血性脑卒中的临床疗效。方法将206例急性缺血性脑卒中患者随机分为研究组和对照组各103例,对照组联合应用尤瑞克林、丁苯酞和阿司匹林三种药物治疗,研究组在对照组的基础上联合高压氧治疗。观察2组治疗效果,采用放射免疫法检测2组血清血栓素B2和内皮素-1水平变化。结果研究组总有效率高于对照组,2组患者治疗后血清血栓素B2和血清内皮素-1水平均低于治疗前,且研究组低于对照组,差异均有统计学意义(P<0.05)。结论应用高压氧联合尤瑞克林、丁苯酞和阿司匹林等药物治疗急性缺血性脑卒中可显著降低血清血栓素B2和内皮素-1水平,神经功能恢复情况更好,值得在临床上推广。
Objective To observe the clinical effects of hyperbaric oxygen combined with triple therapy in the treatment of acute ischemic stroke. Methods A total of 206 patients with acute ischemic stroke were randomly divided into study group (103 cases) and control group (103 cases). The control group was treated with three drugs, namely, uracil, butylphthalide and aspirin. The study group was based on the control group Combined hyperbaric oxygen therapy. The therapeutic effects of the two groups were observed. The levels of serum thromboxane B2 and endothelin-1 in the two groups were detected by radioimmunoassay. Results The total effective rate of the study group was higher than that of the control group. The levels of serum thromboxane B2 and serum endothelin-1 in two groups were lower than those before treatment, and the difference between the two groups was statistically significant (P < 0.05). Conclusion Hyperbaric oxygen combined with norepinephrine, butylphthalide and aspirin in the treatment of acute ischemic stroke can significantly reduce the level of serum thromboxane B2 and endothelin -1, the recovery of neurological function is better and worthy of clinical promotion .