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目的分析高度鳞状上皮内病变(HSIL)患者人乳头状瘤病毒(HPV)感染亚型的分布特点,探讨HPV分型检测在宫颈高度病变筛查中的作用。方法对137例患者进行HPV分型检测,并对HPV基因高危亚型进行分析,分析HPV亚型的检出情况,并比较HPV分型与病理结果。结果 31～40岁组和41～50岁组的阳性率分别为92.2%和89.6%,均高于≤30岁组(73.3%)和≥51岁组(82.6%,P<0.05);单型感染者62例,多重感染者58例,差异无统计学意义(P>0.05)。HPV各类型中,以16及58型感染为多,其次是52、33和18型。单型感染和多重感染均主要以16、58和52型感染为主。高危型阳性的检出率为3.3%(4/120),高于高危型阴性中宫颈癌的检出率(0,P<0.05);高危型阳性炎症、疣症及疣、CINⅠ、CINⅡ和CINⅢ的检出率分别为25.0%(30/120)、28.3%(34/120)、25.0%(30/120)和18.3%(22/120),均高于高危型阴性的检出率(P<0.05)。结论高危型HPV感染以16和58型感染为多,在宫颈病变进行高危型HPV检测对宫颈病变诊治和癌变预防起到指导性的作用。
Objective To analyze the distribution of human papillomavirus (HPV) subtypes in patients with highly squamous intraepithelial lesion (HSIL) and to explore the role of HPV typing in the screening of cervical lesions. Methods Totally 137 patients were tested for HPV genotype. The high risk subtypes of HPV were analyzed. The detection of HPV subtypes was analyzed. HPV typing and pathological results were compared. Results The positive rates were 92.2% and 89.6% in 31-40 years old group and 41-50 years old group, which were higher than those in ≤30 years old group (73.3%) and ≥51 years old group (82.6%, P <0.05) Infected 62 cases, multiple infections in 58 cases, the difference was not statistically significant (P> 0.05). Among HPV types, 16 and 58 were the most common infections, followed by 52, 33 and 18. Single-type infection and multiple infections are mainly 16,58 and 52 type infection. The detection rate of high-risk type positive was 3.3% (4/120), which was higher than that of high-risk type negative cervical cancer (0, P <0.05). High-risk type positive inflammation, warts and warts, CINⅠ, CINⅡ and The detection rates of CINⅢ were higher than those of high-risk type (25.0%, 28.3%, 25.0% and 18.3%, respectively) P <0.05). Conclusions High-risk HPV infection is more common in type 16 and 58, and high-risk HPV testing in cervical lesions plays an instructive role in diagnosis and treatment of cervical lesions.