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目的探讨腹腔热灌注化疗结合免疫治疗机治疗恶性腹水的疗效及其临床分析。方法2010年03月至2012年03月期间,我院诊治的60例恶性腹水患者,随即将其分为对照组(单纯采用腹腔热灌注化疗)和观察组(对照组基础上,联用免疫治疗机治疗),每组各30例,对其临床疗效和不良反应,进行观察和比较。结果 30例对照组患者中,13例完全缓解,8例部分缓解,5例病情稳定,4例病情进展;30例观察组患者中,15例完全缓解,10例部分缓解,4例病情稳定,1例病情进展。与对照组相比(70.0%),观察组的总有效率明显升高(83.3%),P<0.05。30例对照组患者中,有10例出现恶心呕吐,8例腹胀、腹痛,8例骨髓抑制;30例观察组患者中,有7例出现恶心呕吐,6例腹胀、腹痛,4例骨髓抑制。与对照组相比,观察组的总不良反应比率明显降低,P<0.05。结论对于恶性腹水的治疗,腹腔热灌注化疗结合免疫治疗机治疗的疗效显著,并且不良反应少,值得临床推广。
Objective To investigate the efficacy and clinical analysis of intraperitoneal hyperthermic chemotherapy combined with immunotherapy in the treatment of malignant ascites. Methods Between March 2010 and March 2012, 60 patients with malignant ascites diagnosed and treated in our hospital were randomly divided into control group (celiac hyperthermic perfusion chemotherapy alone) and observation group (control group, combined with immunotherapy Machine treatment), 30 cases in each group, its clinical efficacy and adverse reactions were observed and compared. Results Of the 30 patients in the control group, 13 were completely relieved, 8 were partially relieved, 5 were stable and 4 were advanced. Among the 30 patients in the observation group, 15 were completely relieved, 10 were partially relieved, 4 were stable, 1 case of disease progression. Compared with the control group (70.0%), the total effective rate in the observation group was significantly increased (83.3%), P <0.05.30 patients in the control group, nausea and vomiting in 10 cases, 8 cases of bloating, abdominal pain, 8 cases Myelosuppression; nausea and vomiting occurred in 7 of the 30 patients in the observation group, with 6 cases of bloating and abdominal pain and 4 cases of myelosuppression. Compared with the control group, the observation group, the total adverse reaction rate was significantly lower, P <0.05. Conclusion For the treatment of malignant ascites, peritoneal hyperthermic chemotherapy combined with immunotherapy machine treatment of significant effect, and less adverse reactions, is worth clinical promotion.