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从1944年Dodd和Stillman证实了硝基呋喃化合物的抗菌作用以来,5-硝基-2-取代呋喃衍生物已发展为一类重要的抗感染药物,目前已经用于临床上的有以下几种: 1.抗细菌感染:呋哺西林、呋喃妥英、呋喃它酮、呋喃唑酮(亦用于抗滴虫戚染)。 2.抗霉菌感染;呋喃甲醛肟(亦用于抗滴虫感染)。 3.抗血吸虫感染:F-30066、F-30069。它们在化学结构上可以分为两类,即5-硝基呋喃-2-亚麸胺衍生物和β-(5-硝基2-呋喃)-丙烯酰胺衍生物。
Since Dodd and Stillman confirmed the antibacterial effect of nitrofuran compounds in 1944, 5-nitro-2-substituted furan derivatives have developed into a class of important anti-infective drugs and have been used clinically in the following several : 1. Anti-bacterial infections: furosemide Xilin, nitrofurantoin, furan ketone, furazolidone (also used for anti-trichomoniasis). 2. anti-fungal infection; furfural oxime (also used for anti-trichomoniasis infection). 3. Anti-schistosome infection: F-30066, F-30069. They are divided in chemical structure into two groups, namely, 5-nitrofuran-2-ylidene derivative and β- (5-nitro-2-furan) -acrylamide derivative.