IntroductionrnAmlodipine is a dihydropyridine calcium channel blocker (CCB) that inhibits calcium influx into cardiac,vascular smooth muscle cells,and pancreatic beta cells,leading to dilation of arteries and arterioles and reduction in insulin secretion.Oral administration of amlodipine is absorbed slowly but almost completely,with a high oral bioavailability up to 60％-80％.