美国波士顿的Plotkin SR等对原发性神经系统淋巴瘤(PNSL)撰写了一篇综述。PNSL是少见的局限在神经系统的非何杰金淋巴瘤。尽管在过去的十年中对PNSL的治疗取得了重要的进展,但是患有这种疾病的患者很少治愈。直到最近,全脑放射治疗成为了PNSL的标准治疗方案。但是,全脑放射治疗与复发率高以及化疗后的晚期神经毒性相关,特别是对于那些年龄超过60岁的患者。以氨甲喋呤为基础的化疗 Plotkin SR, Boston, USA, et al., Wrote an overview of primary nervous system lymphoma (PNSL). PNSL is a rare non-Hodgkin lymphoma localized in the nervous system. Although significant progress has been made in the treatment of PNSL in the past decade, patients with this disease rarely cure. Until recently, whole brain radiation therapy became the standard treatment for PNSL. However, whole brain radiation therapy is associated with high recurrence rates and advanced neurotoxicity after chemotherapy, especially for those over the age of 60 years. Methotrexate-based chemotherapy