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目的观察益气养阴通络方对糖尿病小鼠足部溃疡的治疗作用,并探讨可能的作用机制。方法 SPF级C57BL/6J雄性小鼠70只,随机抽取10只为正常对照组,其余小鼠腹腔快速注射STZ(120 mg·kg-1)造模及结扎股动脉、股静脉建立糖尿病足(DF)模型,分为模型对照组、二甲双胍+西洛他唑组(西药对照组)、通塞脉片组(中药对照组)、益气养阴通络方高、中、低剂量组。连续用药2周,动态观测各组小鼠的体重、空腹血糖(FBG)、创面大小等指标,检测血清血栓素B2(TXB2)、6-酮-前列腺素F-1α(6-K-PGF-1α)、内皮素-1(ET-1)、hs-C反应蛋白(hs-CRP)、白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)含量。结果与模型对照组相比,益气养阴通络方能降低FBG,缩小溃疡面积,缩短结痂天数,降低hs-CRP、IL-6、TNF-α、TXB2、ET-1含量,升高6-K-PGF-1α含量。结论益气养阴通络方可通过降低血糖、良性调节血管内皮功能、抑制炎症因子释放,促进肉芽组织生长,缩短足部溃疡愈合时间。
Objective To observe the therapeutic effect of Yiqi Yangyin Tongluo Formula on foot ulcer in diabetic mice and to explore its possible mechanism. Methods Seventy male Wistar rats with SPF grade C57BL / 6J were randomly divided into normal control group (n = 10). The other mice were injected intraperitoneally with STZ (120 mg · kg -1) intraperitoneally to model and ligate femoral artery and femoral vein to establish diabetic foot ) Model, divided into model control group, metformin + cilostazol group (western medicine control group), Tongsaimailian group (Chinese medicine control group), Yiqi Yangyin Tongluo Recipe high, medium and low dose groups. After 2 weeks of continuous administration, the body weight, fasting blood glucose (FBG) and wound size of each group were dynamically observed to detect the levels of serum TXB2, 6-K-PGF- 1α, ET-1, hs-CRP, IL-6 and TNF-α were measured. Results Compared with the model control group, Yiqi Yangyin Tongluo Formula can reduce the FBG, reduce the ulcer area, shorten the days of scab and reduce the content of hs-CRP, IL-6, TNF-α, TXB2 and ET- 6-K-PGF-1α content. Conclusion Yiqi Yangyin Tongluo Recipe can reduce granulation tissue growth and shorten the healing time of foot ulcer through lowering blood glucose, regulating vascular endothelial function, inhibiting the release of inflammatory cytokines.