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DNA除了作为一种遗传信息的载体分子之外,还可以通过折叠或组装从而形成特定的二维和三维结构。通过设计DNA分子的结构并探索其与纳米材料之间的相互作用的研究已经引起了国内外学术界的持续关注。DNA功能化的无机纳米材料促进了分析科学、生命科学以及环境科学的快速发展。本文将从疾病分子机制研究、疾病诊断和疾病治疗三个角度出发,探究面向生物医学分析应用的DNA分子功能化的无机纳米材料的设计与组装。除此之外,还对DNA功能化纳米材料技术的发展前景进行了展望。
In addition to DNA as a carrier of genetic information molecules, but also by folding or assembly to form a specific two-dimensional and three-dimensional structure. The research on the interaction between DNA molecules and nano-materials through the design of their structures has drawn the continuous attention of academics at home and abroad. DNA-functionalized inorganic nanomaterials have contributed to the rapid development of analytical sciences, life sciences, and environmental sciences. This article will explore the design and assembly of DNA molecule-functionalized inorganic nanomaterials for biomedical analysis applications from the perspectives of disease molecular mechanisms, disease diagnosis and disease treatment. In addition, the prospect of the development of DNA functionalized nanomaterials technology is also prospected.