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(1) 本实驗以家兔56只,每只接种血吸虫尾蚴300条,將其中37只分成感染当天、第7天、第14天及第21天四組,另外19只作为給藥各組的对照。各組均給予口服同剂型、同剂量酒石酸銻鉀腸溶片,每日每公斤体重30毫克,連续21天。各組均在停藥后第28天进行解剖。(2) 酒石酸銻钾腸溶片口服,对家兔体內血吸虫幼虫发育各阶段的抑制作用:以感染后第14天和第7天开始給藥組为最大,虫体減少率各为96.8%及97.3%;感染后第21天开始給藥組次之,虫体減少率为90.8%。以感染当天开始給藥组为最差,虫体減少率为38.7%。因此我們認为銻剂对家兔体內血吸虫抑制作用的大小,依血吸虫的发育阶段而不同,以生殖器官开始发育至成熟排卯期(感染后弟16—31天)为最大;而在幼虫生殖器官发育以前(感染后第15天以前)的效果最差。在生殖器官成熟后(感染后第35天)給藥的效果,远不如在血吸虫生殖器官发育期間的好,而且安全。
(1) In this experiment, 56 rabbits were inoculated with 300 cercariae of Schistosoma japonicum, 37 of them were divided into four groups on the day of infection, the seventh day, the fourteenth day and the twenty-first day, and the other 19 Control. Each group were given oral dosage form, the same dose of antimony potassium tartrate enteric-coated tablets daily 30 mg per kilogram of body weight for 21 days. All groups were dissected on the 28th day after drug withdrawal. (2) The anti-schistosomica enteric-coated tablets of tartaric acid were orally administered to rabbits in vivo to inhibit the development of schistosomula larvae at the 14th day and the 7th day after infection. The reduction rates of parasites were 96.8% And 97.3% respectively. After 21 days after infection, the treatment group was followed by the reduction rate of parasites was 90.8%. The infection group was the worst on the day of infection, with a reduction rate of 38.7%. Therefore, we believe that the inhibitory effect of antimony on rabbit schistosome in vivo, according to the different stages of development of schistosomiasis to reproductive organs began to mature maturity stage (16-16 days after infection) is the largest; in larvae Before reproductive organ development (before 15 days after infection) the effect is the worst. The effect of administration after the genital mutilation (35 days after infection) is far less favorable and safer than during schistosome reproductive organ development.