The determination of cosmogenic 53Mn in terrestrial formations has important applications. Accelerator mass spectrometry (AMS) is the most sensitive technique to detect minute amounts of 53Mn. 53 Mn measurement techniques have been developed in the past few years on the ΔE-Q3D-equipped AMS system at China Institute of Atomic Energy. The method has recently been further optimized with the goal The determination of cosmogenic 53 Mn in terrestrial formations has important applications. Accelerator mass spectrometry (AMS) is the most sensitive technique to detect minute amounts of 53 Mn. 53 Mn measurement techniques have been developed in the past few years on the ΔE-Q3D-equipped AMS system at China Institute of Atomic Energy. The method has recently been further optimized with the goal