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目的系统评价骨桥蛋白(OPN)表达与中国人肝癌及其临床病理特征的关系。方法计算机检索CBM、CNKI、VIP和Wan Fang Data数据库,搜集有关OPN表达与中国人肝癌及其临床病理特征关系的研究,检索时限均截至2014年7月。由2位研究者按照纳入与排除标准筛选文献、提取资料并评价纳入研究的方法学质量后,采用Rev Man 5.2软件进行Meta分析。结果共纳入10个病例-对照研究,其中肝癌组723例,正常肝组织组102例。Meta分析结果显示:OPN在肝癌组表达较正常对照组高[OR=10.25,95%CI(6.13,17.14)],肝癌包膜不完整组较与包膜完整组表达高[OR=2.71,95%CI(1.58,4.64)];OPN在肝癌单发组与多发组[OR=0.95,95%CI(0.56,1.62)]、高中分化组与低分化组[OR=0.60,95%CI(0.36,1.01)]、临床Ⅰ~Ⅱ期组与临床Ⅲ~Ⅳ期组[OR=0.93,95%CI(0.53,1.63)]的表达差异无统计学意义。结论现有证据表明,OPN可能参与了中国人肝癌发生、发展的全过程,但其是否可作为预后判断的因素,尚待进一步研究。
Objective To evaluate the relationship between osteopontin (OPN) expression and hepatocellular carcinoma in China and its clinicopathological features. Methods CBM, CNKI, VIP and Wan Fang Data were searched by computer. The relationship between OPN expression and clinicopathological features of Chinese hepatocellular carcinoma was collected. The search time was up to July 2014. After two investigators screened the literature for inclusion and exclusion criteria, extracted data, and evaluated the methodological quality of the included studies, the Meta-analysis was performed using Rev Man 5.2 software. Results A total of 10 case-control studies were included, of which 723 were HCC and 102 were normal liver tissue. The results of Meta analysis showed that the expression of OPN in HCC tissues was higher than that in normal controls [OR = 10.25,95% CI (6.13,17.14)], and the expression of OPN in intact and intact HCC tissues was significantly higher than that in intact group [OR = 2.71,95 (OR = 0.95,95% CI (0.56,1.62)]. There was significant difference between OPN group and low differentiated group [OR = 0.60,95% CI , 1.01). There was no significant difference in the clinical stage Ⅰ ~ Ⅱ group and the clinical stage Ⅲ ~ Ⅳ group [OR = 0.93,95% CI (0.53,1.63]]. Conclusions The available evidence shows that OPN may be involved in the whole process of hepatocarcinogenesis in Chinese, but whether it can be used as a prognostic factor remains to be further studied.