目的：了解已烯雌酚在鼻中隔穿孔上皮修复中的疗效。方法选择穿孔直径<1.0c m的鼻中隔穿孔患者30例随机分为2组，治疗组穿孔双侧缘周作1-2m m创口,用浸润已烯雌酚注射液的棉片贴敷,隔日1次，连续7～14d，观察局部黏膜修复情况；对照组采用0.9%氯化钠注射液棉片贴敷，方法同治疗组。结果治疗组15例患者全部愈合,穿孔症状随创面渐渐愈合而消失，2例鼻干燥主诉存在。随访6个月，未发现再穿孔者，无局部和全身不良反应；对照组15例患者有3例穿孔愈合，治愈率与治疗组比较差异有统计学意义p<0.01。结论已烯雌酚注射液在治疗穿孔<1.0c m的鼻中隔穿孔中，疗效确切，无明显手术创伤，操作及观察容易，价格低廉，无不良反应，作为一种非手术治疗鼻中隔穿孔的方法值得临床推广。“,”Objective: To evaluate the repairing effect of diethylstilbestrol injection in mucosa injury of nasal septum. Method Selected nasal septum perforation 30 cases were randomly divided into 2 groups, whose perforation diameter <1.0cm. In the treatment group, 15 cases with perforation of nasal septum were made about 1-2mm new wound surface around perforation, the cotton piece infiltrated by diethylstilbestrol injection was sticked directly to the surface of perforation, once every other day, for 7-14 days, to observe the repair of local mucosal. In the control group, sticking the surface of perforation with the cotton piece infiltrated by 0.9% sodium chloride injection, the method was same as the treatment group. Results In the treatment groups, 15 cases of perforation were cured, the symptoms disappear gradual y, 2 cases of nasal dryness complained of existence. There is no reperforation during fol ow-up six months, and without local and systemic adverse reactions; In the control group of 15 patients, there were 3 cases of perforation were healing, The cure rate of treatment group and control group had significant difference p<0.01.Conclusion The curative effect of diethylstilbestrol injection in the treatment of perforation of the nasal septum (perforation diameter<1.0cm) is definite, and the treatment no obvious operation trauma, operation and observation easily, low price, no adverse reaction, as a kind of non operation treatment for perforation of nasal septum is worthy of clinical application.