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目的:比较甘精胰岛素两种起始剂量调整方案治疗Ⅱ型糖尿病的疗效和安全性。方法:85例T2DM患者分为方法1组(根据病人空腹血糖值决定胰岛素起始剂量)和方法2组(医生根据临床经验自行决定胰岛素起始剂量),两组的年龄、BMI、FPG、HbA1c差异无统计学意义(P>0.05)。结果:方法1组和方法2组治疗均有效,FPG、HbA1c均较治疗前明显下降,低血糖发生率无统计学差异(P>0.05)。但两组达到相同血糖水平所需的治疗时间上,方法1组要明显少于方法2组(P<0.05)。结论:根据病人空腹血糖值决定胰岛素起始剂量的方法,安全有效的控制高血糖,易于临床医生掌握,值得推广。
Objective: To compare the efficacy and safety of two initial dosage regimens of insulin glargine in the treatment of type 2 diabetes mellitus. Methods: Eighty-five patients with T2DM were divided into two groups according to their age, BMI, FPG, HbA1c (Method 1) The difference was not statistically significant (P> 0.05). Results: The results showed that the effective rate of FPG and HbA1c in group 1 and group 2 were significantly lower than those before treatment, and the incidence of hypoglycemia was no significant difference (P> 0.05). However, the time required for treatment to achieve the same blood glucose level in both groups was significantly less than that in method 2 group (P <0.05). Conclusion: According to the fasting blood glucose level of patients, the method of determining the initial dose of insulin, safe and effective control of hyperglycemia, easy to grasp by clinicians, and worthy of promotion.