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对比剂肾病(CIN)是指患者接受治疗或检查的过程中,注射对比剂后,出现血清肌酐水平的上升,导致肾功能下降的疾病。目前,随着对比剂应用的日趋广泛和CIN发病率的逐年上升,对CIN的研究逐渐增多。通过研究,对CIN的发病率、发病机制及危险因素等方面有了比较深入的认识,更多的研究针对CIN的预防措施展开。大多数研究结果认为,水化治疗和抗氧化药物的使用可以有效预防CIN发生,更多的预防手段正在被不断的研究中。该文将对CIN的基础研究进展作一综述,对CIN的预防措施进展作重点阐述。
Contrast agent nephropathy (CIN) refers to the patient undergoing treatment or examination, the injection of contrast agent, the serum creatinine levels rise, leading to decreased renal function disease. At present, with the increasingly wide range of contrast agents and the increasing incidence of CIN, the research on CIN is gradually increasing. Through research, the incidence of CIN, pathogenesis and risk factors have a more in-depth understanding of more research for CIN prevention measures. Most studies concluded that the use of hydration therapy and anti-oxidant drugs can effectively prevent the occurrence of CIN, and more preventive measures are being constantly studied. This article will review the progress of CIN basic research and highlight the progress of CIN preventive measures.